Triethylamine → (S)-1-Benzyl-3-mesyloxypyrrolidine

HRID 129195

反応式

HRID 129195 の反応式
[CH2:1]([N:8]1[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23].C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:12][CH2:11][C@H:10]([O:13][S:22]([CH3:21])(=[O:24])=[O:23])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 2733875(S)-(-)-1-Benzyl-3-pyrrolidinol

生成物 1

HCID 10934081(S)-1-Benzyl-3-mesyloxypyrrolidine収率 98%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

(S)-1-Benzyl-3-hydroxypyrrolidine (1003.5 g, 5.66 mol) was dissolved in toluene (12 L) and the solution stirred and cooled to 0°-5° C. Triethylamine (680 g, 6.67 mol) was added followed by methanesulfonyl chloride (760 g, 6.63 mol) over a 4 hour period. A slurry formed after 30 minutes. The mixture was allowed to stir an additional 1.5 hours and 7% sodium bicarbonate (12 L) was added to the reaction mixture and the organic layer separated. The aqueous layer was extracted with toluene (4 L and 2 L) and the combined organic layers washed with saturated sodium bicarbonate (3×6 L), dried over MgSO4 and concentrated under reduced pressure to give (S)-1-benzyl-3-mesyloxypyrrolidine as a yellow oil (1.41 kg, 98%):

後処理

  1. temperaturecooled to 0°-5° C
  2. customA slurry formed after 30 minutes
  3. stirringto stir an additional 1.5 hours
  4. customthe organic layer separated
  5. extractionThe aqueous layer was extracted with toluene (4 L and 2 L)
  6. washthe combined organic layers washed with saturated sodium bicarbonate (3×6 L)
  7. dry with materialdried over MgSO4
  8. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-598cb616651a47af9cf13705182b4fa2
出典データセット
uspto-grants-1995_11
特許番号
US05466828

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