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Methyl 4-(trifluoromethyl)nicotinate → (4-(Trifluoromethyl)pyridin-3-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-(trifluoromethyl)nicotinate | HCID 2775680 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-(Trifluoromethyl)pyridin-3-yl)methanol | HCID 18914105 | — |
反応手順
To a stirred suspension of LAH (0.64 g, 17.0 mmol) in THF (30 mL) at -78° C. was added dropwise methyl 4-trifluoromethylnicotinate (1.74 g, 8.48 mmol) in THF (20 mL). The mixture was stirred for 1 h then carefully quenched with aqueous NaHCO3 (80 mL) and extracted with CH2Cl2 (3×100 mL). The combined organic extracts were dried (Na2SO4) and concentrated in vacuo to give 3-hydroxymethyl-4-trifluoromethylpyridine as an oil (TLC: Rf = 0.35 (1:1 hexane:EtOAc)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05756497 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-825762a821df49e381027f649ef3fc7c |
| 出典メモ | uspto-grants-1998_05 |