Ammonia → 4-Methoxyphenylbenzo[d]oxazole-4-carboxamide

HRID 1292138ノート

反応式

HRID 1292138 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20]C)=O)[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.[NH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([NH2:22])=[O:20])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 222Ammonia2 回HCID 14616764Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate

生成物 1

HCID 183546064-Methoxyphenylbenzo[d]oxazole-4-carboxamide

実験手順

Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate was dissolved in liquid ammonia (30 ml) and sealed in an autoclave. The reaction mixture was left at 55° C., 20 bar for >20 hours. Once the reaction was complete the ammonia was removed and the resulting solid recrystallised from boiling ethyl acetate and petrol.

後処理

  1. customsealed in an autoclave
  2. waitThe reaction mixture was left at 55° C.
  3. wait20 bar for >20 hours
  4. customwas removed
  5. customthe resulting solid recrystallised

出典と根拠

ORDレコード
ord-08a35897cb694c50b8db1cc76a434d43
出典データセット
uspto-grants-1998_05
特許番号
US05756510

反応ノート

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