Hydrochloric Acid → 2-Methoxy-4-(4-piperidyloxy)benzoic acid
反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]参加物
4
実験手順
2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.
後処理
- customThe mixture was evaporated in vacuo
- concentrationthe residue concentrated from ether three times
出典と根拠
- ORDレコード
- ord-f036814dc39d4a55a79d10b483490ec1
- 出典データセット
- uspto-grants-1998_05
- 特許番号
- US05756504
反応ノート
読み込み中…