Ammonia → 2-Chloro-3-nitroquinolin-4-amine

HRID 1292485ノート

反応式

HRID 1292485 の反応式
[Cl:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH3:16]>CO>[NH2:16][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([Cl:1])[C:11]=1[N+:12]([O-:14])=[O:13]

参加物

4

反応物 2

HCID 222AmmoniaHCID 27851382,4-Dichloro-3-nitroquinoline

生成物 1

HCID 218980422-Chloro-3-nitroquinolin-4-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
45 °C

実験手順

2,4-dichloro-3-nitroquinoline (5.3 g, 0.218 mol) was combined with 75 mL of 15 percent ammonia in methanol and the mixture was heated at about 45° C. for about 4 hours. The reaction mixture was cooled to room temperature, and the precipitated product was removed by filtration. The volume of methanol was reduced to about 35 mL, and the precipitated product was removed by filtration. The volume of methanol was then reduced to about 10 mL and the precipitated product was again removed by filtration. The combined solids were stirred in aqueous sodium bicarbonate, filtered, and dried to afford a solid product 4-amino-2-chloro-3-nitroquinoline.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customthe precipitated product was removed by filtration
  3. customthe precipitated product was removed by filtration
  4. customthe precipitated product was again removed by filtration
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-f6a1c53dd5534e4ca0bdbe6a80ac5547
出典データセット
uspto-grants-1998_05
特許番号
US05756747

反応ノート

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