Ammonia → N-BENZYLIDENE-2-PROPYNYLAMINE

HRID 1292541ノート

反応式

HRID 1292541 の反応式
CS(O[CH2:6][C:7]#[CH:8])(=O)=O.[CH:9](=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[NH3:17]>C1(C)C=CC=CC=1>[CH:9](=[N:17][CH2:6][C:7]#[CH:8])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 240BenzaldehydeHCID 305925propargyl mesylate

生成物 1

HCID 4172560N-BENZYLIDENE-2-PROPYNYLAMINE収率 85%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Propargyl methanesulfonate (31.6 g, 0.236 mol) and benzaldehyde (31.9 g, 0.3 mol) were dissolved in 103 g of toluene and an aqueous 28% ammonia solution (122 g, 2 mol) was added dropwise at 21° C. over 8 hours to the solution, followed by stirring at the same temperature for 15 hours. After separating, the resultant organic phase was washed with water and concentrated until the weight became 57.3 g to obtain a toluene solution containing 28.6 g (yield: 85%) of N-benzylidene-2-propynylamine.

後処理

  1. customAfter separating
  2. washthe resultant organic phase was washed with water
  3. concentrationconcentrated until the weight
  4. customto obtain a toluene solution

出典と根拠

ORDレコード
ord-5ddd84546c0b4594a50cd7d2ef279fcb
出典データセット
uspto-grants-1998_05
特許番号
US05756769

反応ノート

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