3-(Methylamino)propane-1,2-diol → 3-[(6-Methoxy-3-nitro-2-pyridyl)methylamino]propane-1,2-diol
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.[CH3:13][NH:14][CH2:15][CH:16]([OH:19])[CH2:17][OH:18]>C(O)C>[CH3:12][O:11][C:4]1[N:3]=[C:2]([CH2:13][NH:14][CH2:15][CH:16]([OH:19])[CH2:17][OH:18])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1参加物
4
実験手順
4 g (0.0219 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 50 ml of ethanol and 4.15 ml (0.0438 mol) of 3-methylamino-1,2-dihydroxypropane are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 4.74 g of yellow powder are obtained, ie a yield of 87.1%.