化工社化工社 化学情報印刷レポート · 研究参考用
1-Bromo-4-iodobenzene → 2-{4-[3-(4-Bromo-phenyl)-prop-2-ynyloxy]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-4-iodobenzene | HCID 11522 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 2-(4-Prop-2-ynyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 86619656 | — |
| 触媒 | Palladium Chloride | HCID 24290 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-{4-[3-(4-Bromo-phenyl)-prop-2-ynyloxy]-phenoxymethyl}-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68429658 | 33.8% |
反応手順
General procedure A was followed using the product from step 3 Example 1 (266 mg, 0.803 mmol), p-bromo iodobenzene (156.5 mg, 0.669 mmol), PdCl2 (2.5 mg, 0.014 mmol), pyrrolidine (0.277 mL, 3.34 mmol), water (0.844 mL) to give the title compound (110 mg, 33.8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728032B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f40eca44ce424484a1a2bde3e1058889 |
| 出典メモ | uspto-grants-2010_06 |