化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 2,4-Dichloro-6-(2,4-difluoro-phenoxy)-quinazoline | HCID 58820195 | — |
| 生成物 | 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine | HCID 58905130 | — |
反応手順
Compound (1F) (21 g, 0.06 mol) was suspended in ammonia (100 mL of 2.0 M solution in MeOH) and the solution formed after 30 min was stirred at room temperature for 18 h. The precipitate was filtered, the concentrated filtrate triturated with EtOAc, and the organic layers were combined to yield 21.5 g of 2-chloro-6-(2,4-difluorophenoxy)-quinazolin-4-ylamine (1G).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07238698B2 |
| 出典データセット | uspto-grants-2007_07 |
| ORD ID | ord-9a55840aab77422bbbf1d8a693a522b8 |
| 出典メモ | uspto-grants-2007_07 |