関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Nitrofungin | HCID 12074 | — |
| 反応物 | Hydrogen chloride dimer | HCID 6410751 | — |
| 生成物 | 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine | HCID 17469433 | 52% |
反応手順
2-chloro-4-nitro phenol 10 g (57.6 mmol, 1 eq), 2-pycolyl chloride hydrogen chloride 9.45 g (57.6 mmol, 1 eq) cesium carbonate 41.3 (126.8 mmol, 2.2 eq) and sodium iodide 8.64 g (57.6 mmol, 1 eq) were suspended in 200 mL acetonitrile. The reaction mixture was stirred at 60° C. for 5 h. The resulted suspension was filtered and washed with 400 mL water, yielding 2-(2-chloro-4-nitro-phenoxymethyl)-pyridine (8 g, 52%) as a red solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07238701B2 |
|---|
| 出典データセット | uspto-grants-2007_07 |
|---|
| ORD ID | ord-5dc39435a1b14a1da62c148cd06bcb13 |
|---|
| 出典メモ | uspto-grants-2007_07 |
|---|
