Toluene → 8-Azabicyclo[3.2.1]octane hydrochloride

HRID 1293147ノート

反応式

HRID 1293147 の反応式
[C@@H:1]12[N:8](C)[C@@H:5]([CH2:6][CH2:7]1)[CH2:4][CH2:3][CH2:2]2.[Cl:10]C(OC(Cl)C)=O.C1(C)C=CC=CC=1>CO>[ClH:10].[CH:5]12[NH:8][CH:1]([CH2:7][CH2:6]1)[CH2:2][CH2:3][CH2:4]2

参加物

5

反応物 3

HCID 1140TolueneHCID 5213051-Chloroethyl chloroformateHCID 637986Tropane

生成物 1

HCID 5222728-Azabicyclo[3.2.1]octane hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of tropane (900 mg), 1-chloroethyl chloroformate (1 ml), and toluene (20 ml) was heated and refluxed for 6 hours. After that, methanol (10 ml) was added to the reaction solution, and further refluxed for 4 hours. The solvent was distilled to yield the title compound (850 mg).

後処理

  1. temperaturewas heated
  2. temperaturerefluxed for 6 hours
  3. temperaturefurther refluxed for 4 hours
  4. distillationThe solvent was distilled

出典と根拠

ORDレコード
ord-fe22afe8ae504626af06b4ebceeec28c
出典データセット
uspto-grants-2007_07
特許番号
US07238720B2

反応ノート

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