HCID 57572271、化合物 → Methyl 4-[1-({[5-Fluoro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)-1-methylethyl]benzoate
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:16](NCC2C=CC(C(OC)=O)=CC=2)=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.[NH2:30][C:31]([C:34]1[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=1)([CH3:33])[CH3:32]>>[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:30][C:31]([C:34]2[CH:43]=[CH:42][C:37]([C:38]([O:40][CH3:41])=[O:39])=[CH:36][CH:35]=2)([CH3:32])[CH3:33])=[O:17])[C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)=[N:6][CH:7]=1参加物
3
実験手順
The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-(1-amino-1-methylethyl)benzoate: 1H-NMR (CDCl3) δ 8.33 (1H, br.s), 8.24 (1H, dd, J=8.2, 3.1 Hz), 8.04–7.99 (3H, m), 7.51 (2H, dd, J=6.7, 1.9 Hz), 7.18–7.16 (4H, m), 3.90 (3H, s), 1.80 (6H, s); MS (ESI) m/z 427 (M+H)+, 425 (M−H)−.
出典と根拠
- ORDレコード
- ord-36d56cd69dfb4853a72f119c13a5ce93
- 出典データセット
- uspto-grants-2007_07
- DOI