3-Methoxy-5-Methylphenol → tert-Butyl 4-[(1S)-1-({[5-chloro-2-(3-methoxy-5-methylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

HRID 1293236

反応式

HRID 1293236 の反応式
Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:26])=[CH:4][N:3]=1.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([OH:36])[CH:32]=[C:33]([CH3:35])[CH:34]=1>>[Cl:26][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:36][C:31]2[CH:32]=[C:33]([CH3:35])[CH:34]=[C:29]([O:28][CH3:27])[CH:30]=2)=[N:3][CH:4]=1

参加物

3

反応物 2

HCID 766743-Methoxy-5-MethylphenolHCID 57572256tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate

生成物 1

HCID 69420534tert-Butyl 4-[(1S)-1-({[5-chloro-2-(3-methoxy-5-methylphenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoate

実験手順

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 3-methoxy-5-methylphenol: 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.6 Hz), 8.17 (2H, d, J=2.8 Hz), 7.95 (2H, dd, J=6.6, 1.8 Hz), 7.39 (2H, d, J=8.1 Hz), 6.67 (1H, br.s), 6.55–6.51 (2H, m), 5.40–5.30 (1H, m), 3.80 (3H, s), 2.37 (3H, s), 1.58 (9H, s), 1.57 (3H, d, J=6.8 Hz).

出典と根拠

ORDレコード
ord-a3c087b0aeec4473b4c5a9425c4d719d
出典データセット
uspto-grants-2007_07
特許番号
US07238714B2

関連ノート

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