(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → Methyl 4-[(1S)-1-({5-chloro-2-[(5-fluoropyridin-3-yl)oxy]benzoyl}amino)ethyl]benzoate
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[NH2:20][C@H:21]([C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1)[CH3:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)=[C:6]([CH:10]=1)[C:7]([NH:20][C@H:21]([C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1)[CH3:22])=[O:9]参加物
3
実験手順
The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-[(5-fluoropyridin-3-yl)oxy]benzoic acid (step 2) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.33 (1H, d, J=2.3 Hz), 8.23 (1H, d, J=2.3 Hz), 8.11 (1H, d, J=2.7 Hz), 7.95 (2H, d, J=8.2 Hz), 7.45 (1H, dd, J=8.7, 2.8 Hz), 7.38–7.25 (1H, m), 7.30 (2H, d, J=8.2 Hz), 6.95 (1H, td, J=8.9, 2.3 Hz), 6.91 (1H, d, J=8.7 Hz), 5.38–5.25 (1H, m), 3.90 (3H, s), 1.50 (3H, d, J=6.9 Hz).