2-Chlorobenzenesulfonamide → 5-Chloro-N-{(1S)-1-[4-({[(2-chlorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}-2-(4-fluorophenoxy)nicotinamide

関与物質

反応手順

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 2-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.6 Hz), 8.23–8.12 (2H, m), 8.04 (1H, d, J=2.6 Hz), 7.87 (1H, d, J=7.3 Hz), 7.47–7.16 (5H, m), 7.15–7.01 (5H, m), 5.45–5.25 (1H, m), 1.48 (3H, d, J=6.4 Hz); MS (ESI) m/z 588 (M+H)+, 586 (M−H)−.

情報源と証拠