4-[(1S)-1-({[5-Chloro-2-(4-fluorophenoxy)pyridin-3-YL]carbonyl}amino)ethyl]benzoic acid → 5-Chloro-2-(4-fluorophenoxy)-N-{(1S)-1-[4-({[(3-methoxyphenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}nicotinamide

関与物質

反応手順

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 3-methoxybenzenesulfonamide: 1H-NMR (CDCl3) δ 8.51 (1H, d, J=2.8 Hz), 8.13 (1H, d, J=2.8 Hz), 8.09 (1H, d, J=7.0 Hz), 7.73 (2H, d, J=8.4 Hz), 7.70–7.64 (2H, m), 7.49–7.39 (3H, m), 7.21–7.08 (5H, m), 5.37–5.25 (1H, m), 3.88 (3H, s), 1.56 (3H, d, J=6.8 Hz); MS (ESI) m/z 584 (M+H)+, 582 (M−H)−.

情報源と証拠