化工社化工社 化学情報印刷レポート · 研究参考用
Lithium Hydroxide → Oxane-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester | HCID 2773520 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Oxane-4-carboxylic acid | HCID 219302 | 94.6% |
反応手順
Methyl tetrahydro-2H-pyran-4-carboxylate (270 g, 1.87 mol) was diluted in ethanol (2 L). A 1M aqueous LiOH solution (1870 ml, 1.87 mol) was added (slight exotherm) at RT and the reaction was stirred for 3 hrs. The reaction mixture was concentrated to ca. 1 L and acidified to pH 2 with 5M HCl solution. The aqueous solution was extracted with ethyl acetate (3×600 ml) and the organic layer was dried (MgSO4) and evaporated to dryness to give a white solid (230.3 g, 94%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728035B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-76e9fb2770784b0a8abd2575d9391bec |
| 出典メモ | uspto-grants-2010_06 |