Methylamine → 3-amino-N,3-dimethylbutanamide
反応式
Cl.[NH2:2][C:3]([CH3:10])([CH3:9])[CH2:4][C:5](OC)=[O:6].[CH3:11][NH2:12]>>[CH3:11][NH:12][C:5](=[O:6])[CH2:4][C:3]([NH2:2])([CH3:10])[CH3:9]参加物
3
実験手順
A mixture of methyl 3-amino-3-methyl-butyrate hydrochloride (10.5 g; 62.6 mmoles) and methyl amine (33% solution in ethanol; 55 ml) is refluxed for 18 hours. The solvent is evaporated, the crude is dissolved in methylene chloride (100 ml) and washed with a saturate aqueous solution of sodium chloride (10 ml). After drying over sodium sulphate and evaporation of the solvent to dryness, N-methyl-3-amino-3-methyl-butyramide is obtained; chromatographically pure colorless oil (T.L.C., eluent--methylene chloride:methanol:NH4OH=80:15:1)
後処理
- temperatureis refluxed for 18 hours
- customThe solvent is evaporated
- dissolutionthe crude is dissolved in methylene chloride (100 ml)
- washwashed with a saturate aqueous solution of sodium chloride (10 ml)
- dry with materialAfter drying over sodium sulphate and evaporation of the solvent to dryness
出典と根拠
- ORDレコード
- ord-fa49d532d27545ccb08172229df5e489
- 出典データセット
- uspto-grants-1995_11
- 特許番号
- US05468746
反応ノート
読み込み中…