Benzoic Acid → rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

HRID 129429ノート

反応式

HRID 129429 の反応式
C([N:9]1[CH2:17][C@@H:16]2[C@@H:11]([N:12]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:13][CH2:14][O:15]2)[CH2:10]1)(=O)C1C=CC=CC=1.Cl.C(O)(=O)C1C=CC=CC=1>O>[CH2:18]([N:12]1[C@@H:11]2[C@@H:16]([CH2:17][NH:9][CH2:10]2)[O:15][CH2:14][CH2:13]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 243Benzoic AcidHCID 313Hydrochloric AcidHCID 53682667cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

生成物 1

HCID 10856960rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

91 g (0.265 mol) of cis-8-benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are refluxed overnight with 200 ml of concentrated hydrochloric acid and 140 ml of water. The batch is cooled and the benzoic acid suctioned off. The batch is concentrated to half its original volume, adjusted to alkalinity with potassium carbonate, extracted with chloroform, dried over potassium carbonate, concentrated, and distilled.

後処理

  1. temperatureThe batch is cooled
  2. concentrationThe batch is concentrated to half its original volume
  3. extractionextracted with chloroform
  4. dry with materialdried over potassium carbonate
  5. concentrationconcentrated
  6. distillationdistilled

出典と根拠

ORDレコード
ord-e4fddf6a3d634a8ea900c4f13e228d4e
出典データセット
uspto-grants-1995_11
特許番号
US05468742

反応ノート

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