関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | ethyl (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylate | HCID 66578655 | — |
| 溶媒 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 生成物 | 2-(4-Bromophenyl)cyclopropanecarboxylic acid | HCID 301541 | — |
反応手順
To a solution of ester from step 1 in THF-MeOH (4:1, 0.5M) was added LiOH (3 eq, 2M) and the mixture was stirred at 50° C. for 1 h. The organic solvent evaporated, aqueous was acidified with HCl 1N and the acid extracted with EtOAc (3×). The organic was washed with brine, dried and solvent evaporated to afford 2-(4-bromophenyl)cyclopropanecarboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07238706B2 |
|---|
| 出典データセット | uspto-grants-2007_07 |
|---|
| ORD ID | ord-01d029b9507845d591f84661edc5446c |
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| 出典メモ | uspto-grants-2007_07 |
|---|
