関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 1-Benzyl-1,4-diazepane | HCID 228365 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Benzyl-4-(4-nitrophenyl)-[1,4]diazepane | HCID 13007957 | — |
反応手順
Fluoronitrobenzene (3.09 g, 21.9 mmol) is dissolved in water (14 ml), and then potassium carbonate (3.64 g, 26.28 mmol) and 1-benzylhomopiperazine (5 g, 26.28 mmol) are added. The medium is heated at 90° C. for 4 h 20 min and then cooled to room temperature. The precipitate formed is filtered, and a yellow solid is obtained. 6.30 g (92.5%) of product are recovered.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07241317B2 |
|---|
| 出典データセット | uspto-grants-2007_07 |
|---|
| ORD ID | ord-9ac02f125e9f40809ba6a88309620c1f |
|---|
| 出典メモ | uspto-grants-2007_07 |
|---|
