Hydrochloric Acid → Dapivirine HCl

HRID 1294426ノート

反応式

HRID 1294426 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]2[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=2)[N:12]=1.[ClH:26].CC(O)C>C(O)C>[ClH:26].[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]2[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=2)[N:12]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 214347Dapivirine

生成物 1

HCID 22398432Dapivirine HCl収率 86%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile (0.0015 mol) was stirred in boiling ethanol (8 ml). 6 M HCl in 2-propanol (0.0015 mol) was added and the salt was allowed to crystallize out overnight at room temperature. The precipitate was filtered off, washed with 2-propanol and dried, yielding 0.47 g (86%) of 4-[[4-[(2,4,6-trimethyl-phenyl)amino]-2-pyrimidinyl]amino]benzonitrile hydrochloride (1:1) (comp. 31).

後処理

  1. customto crystallize out overnight at room temperature
  2. filtrationThe precipitate was filtered off
  3. washwashed with 2-propanol
  4. customdried

出典と根拠

ORDレコード
ord-b25071f9a70f4d6985e614064e8bc147
出典データセット
uspto-grants-2007_07
特許番号
US07241458B1

反応ノート

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