3-[(1-benzyl-4-piperidyl)oxy]propanenitrile → 200868-41-3
反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][CH2:16][C:17]#[N:18])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[CH2:1]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
10.0 g (40.9 mmol) 3-(1-benylpiperidin-4-yloxy)-propionitrile are dissolved in 100 ml ethanol and added to a spatula tip of Raney-Nickel. The mixture is stirred at RT under hydrogen atmosphere until the uptake of the theoretical amount of hydrogen (ca. two days). The mixture is filtered from the catalyst and the solvent is removed under vacuum. The residue is distilled in a bulb tube apparatus. Yield of colorless oil: 7.5 g (73%).
後処理
- filtrationThe mixture is filtered from the catalyst
- customthe solvent is removed under vacuum
- distillationThe residue is distilled in a bulb tube apparatus
出典と根拠
- ORDレコード
- ord-8f0bc9ba11564026af81e54f68306f68
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07241745B2
反応ノート
読み込み中…