Hydrochloric Acid → 1-(5-{[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl]amino}thien-2-yl)ethanone Hydrochloride
反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]3[S:21][C:20]([C:22](=[O:24])[CH3:23])=[CH:19][CH:18]=3)=[CH:12][CH:11]=1)[CH2:2]2.[ClH:25]>C(OCC)(=O)C>[ClH:25].[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([O:9][C:10]1[CH:11]=[CH:12][C:13]([NH:16][C:17]3[S:21][C:20]([C:22](=[O:24])[CH3:23])=[CH:19][CH:18]=3)=[CH:14][CH:15]=1)[CH2:2]2参加物
4
実験手順
The product of Example 25A (40 mg, 0.12 mmol) was treated with HCl (Aldrich, in dioxane, 4M, 0.2 mL, 0.8 mmol) in ethyl acetate (3 mL) at ambient temperature for 10 h. The title compound was obtained as solid (37 mg, yield, 64%). 1H NMR (MeOH-d4, 300 MHz) δ 1.82–2.19(m, 3H), 2.30–2.38 (m, 1H), 2.41 (s, 3H), 2.46–2.55 (m, 1H), 3.23–3.47 (m, 5H), 3.76–3.84 (m, 1H), 4.78–4.85 (m, 1H), 6.40 (d, J=4.4 Hz, 1H), 7.00 (d, J=8.8 Hz, 2H), 7.25 (d, J=8.8 Hz, 2H), 7.65 (d, J=4.4 Hz, 1H) ppm. MS (DCl/NH3) m/z 343 (M+H)+.