Hydrochloric Acid → Ethyl 2-(2-methylpyridin-3-yl)ethanimidoate hydrochloride

HRID 1294704

反応式

HRID 1294704 の反応式
[CH3:1][C:2]1[C:7]([CH2:8][C:9]#[N:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([OH:13])[CH3:12].[ClH:14]>C(Cl)Cl>[ClH:14].[CH3:1][C:2]1[C:7]([CH2:8][C:9](=[NH:10])[O:13][CH2:11][CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 190992862-(2-Methylpyridin-3-yl)acetonitrile

生成物 1

HCID 69411260Ethyl 2-(2-methylpyridin-3-yl)ethanimidoate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Through a stirred solution of Example 20A (1.7 g, 12.86 mmol) in absolute ethanol (0.89 g, 19.35 mmol) and anhydrous methylene chloride (25 ml) was bubbled with hydrogen chloride gas for 20 min. The mixture was allowed to stand overnight in the refrigerator. The product was precipitated with anhydrous ether and filtered to obtain the title compound, which was immediately used in the next step. MS (ESI+) m/z 180 (M+H)+.

後処理

  1. customThe product was precipitated with anhydrous ether
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-f5ea94eab2534c5faee47406155d52cb
出典データセット
uspto-grants-2007_07
特許番号
US07241776B2

関連ノート

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