関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chloro-6-ethoxybenzo[d]thiazole | HCID 350015 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 6-Ethoxy-2-piperazin-1-yl-1,3-benzothiazole | HCID 28470888 | — |
反応手順
A mixture of 1.36 mmol 2-chloro-6-ethoxy-benzothiazole (CA=[79071-17-3]), 3.00 mmol of piperazine and 3.00 mmol of triethylamine in 5 ml of tetrahydrofuran in a sealed tube was heated at 160° C. for 5 min under microwave irradiation. The reaction mixture was concentrated, and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07241761B2 |
|---|
| 出典データセット | uspto-grants-2007_07 |
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| ORD ID | ord-ed6dfc162bde45228b20d9d792863b02 |
|---|
| 出典メモ | uspto-grants-2007_07 |
|---|
