Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)- → (2,4-Dimethoxyphenyl)[2-fluoro-3-(trifluoromethyl)phenyl]methanone

HRID 1294871ノート

反応式

HRID 1294871 の反応式
[F:1][C:2]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:18][O:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:21]=1[Mg]Br>>[CH3:18][O:19][C:20]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:21]=1[C:4]([C:3]1[CH:10]=[CH:11][CH:12]=[C:13]([C:14]([F:15])([F:16])[F:17])[C:2]=1[F:1])=[O:5]

参加物

3

反応物 2

HCID 11196047Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-HCID 178491918HCID 178491918、化合物

生成物 1

HCID 67021176(2,4-Dimethoxyphenyl)[2-fluoro-3-(trifluoromethyl)phenyl]methanone

実験手順

Prepared according to Method A step B from 2-fluoro-3-trifluoromethyl-N-methoxy-N-methylbenzamide (4.42 g, 17.6 mmol) and 2,4-dimethoxyphenylmagnesium bromide (32 mL, 0.5 M in THF) to give 1.67 g of the title compound as a white solid.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-ebf767f84c124dd0bbb8d4dca5b9a741
出典データセット
uspto-grants-2007_07
特許番号
US07241791B2

反応ノート

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