2,2',4,4'-Tetrahydroxybenzophenone → 4-(6-hydroxy-1-propyl-1H-indazol-3-yl)benzene-1,3-diol

反応式

O[C:2]1[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[OH:13])=O.C([O-])(=O)C.[Na+].C(O)(=O)C(O)=O.[CH2:30]([NH:33][NH2:34])[CH2:31][CH3:32]>>[OH:18][C:16]1[CH:17]=[C:2]2[C:3]([C:4]([C:6]3[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=3[OH:13])=[N:34][N:33]2[CH2:30][CH2:31][CH3:32])=[CH:14][CH:15]=1

参加物

反応物 3

HCID 85712,2',4,4'-Tetrahydroxybenzophenone

HCID 96079Hydrazine, propyl-, ethanedioate (1:1)

HCID 517045Sodium Acetate

生成物 1

HCID 1355118634-(6-hydroxy-1-propyl-1H-indazol-3-yl)benzene-1,3-diol収率 52.8%

実験手順

Prepared according to Method B from 2,2′,4,4′-tetrahydroxybenzophenone (0.123 g, 0.5 mmol), sodium acetate (0.164 g, 2 mmol) and propylhydrazine oxalate (0.164 g, 1.0 mmol) to give 0.075 g of product as a pink solid.