Cyclohexene → 4-(1-isopropyl-7-methyl-1H-indazol-3-yl)phenol

反応式

[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[C:6]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=2)=[N:5]1)([CH3:3])[CH3:2].B(Br)(Br)Br.C1CCCCC=1>>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[C:6]([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=2)=[N:5]1)([CH3:3])[CH3:2]

参加物

反応物 3

HCID 8079Cyclohexene

HCID 25134Boron tribromide

HCID 688843421-isopropyl-3-(4-methoxyphenyl)-7-methyl-1H-indazole

生成物 1

HCID 1354381754-(1-isopropyl-7-methyl-1H-indazol-3-yl)phenol収率 50.7%

実験手順

Prepared according to Method D step C from 1-isopropyl-3-(4-methoxyphenyl)-7-methyl-1H-indazole (0.057 g, 0.20 mmol), boron tribromide (0.094 mL, 1.0 mmol) and 0.3 mL of cyclohexene to give the product (0.027 g) as an off-white solid.

後処理

customPrepared

出典と根拠

ORDレコード: ord-6b7b2001946b4c35b4ac8d8644184576
出典データセット: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07241791B2

反応ノート

読み込み中…