Cyclohexene → 4-(7-chloro-1-pentyl-1H-indazol-3-yl)phenol

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:16]1[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=1.B(Br)(Br)Br.C1CCCCC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:16]1[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=1

参加物

反応物 3

HCID 8079Cyclohexene

HCID 25134Boron tribromide

HCID 688821427-chloro-3-(4-methoxyphenyl)-1-pentyl-1H-indazole

生成物 1

HCID 1355245314-(7-chloro-1-pentyl-1H-indazol-3-yl)phenol収率 64.9%

実験手順

Prepared according to Method D step C from 7-chloro-3-(4-methoxyphenyl)-1-pentyl-1H-indazole (0.070 g, 0.23 mmol), boron tribromide (0.094 mL, 1.0 mmol) and 0.3 mL of cyclohexene to give the product (0.047 g) as an off-white solid.