Cyclohexene → 4-(7-chloro-1-isopropyl-1H-indazol-3-yl)phenol

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:11]([CH3:13])[CH3:12])[N:8]=[C:7]2[C:14]1[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=1.B(Br)(Br)Br.C1CCCCC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:11]([CH3:12])[CH3:13])[N:8]=[C:7]2[C:14]1[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=1

参加物

反応物 3

HCID 8079Cyclohexene

HCID 25134Boron tribromide

HCID 688843687-chloro-1-isopropyl-3-(4-methoxyphenyl)-1H-indazole

生成物 1

HCID 1354742744-(7-chloro-1-isopropyl-1H-indazol-3-yl)phenol収率 29.1%

実験手順

Prepared according to Method D step C from 7-chloro-1-isopropyl-3-(4-methoxyphenyl)-1H-indazole (0.093 g, 0.30 mmol), boron tribromide (0.094 mL, 1.0 mmol) and 0.3 mL of cyclohexene to give the product (0.025 g) as an off-white solid.

後処理

customPrepared

出典と根拠

ORDレコード: ord-b1498164d18242cdb5dfc574d051ea4c
出典データセット: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07241791B2

反応ノート

読み込み中…