Cyclohexene → 4-(2-cyclopentyl-7-fluoro-2H-indazol-3-yl)phenol

反応式

[CH:1]1([N:6]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21]C)=[CH:17][CH:16]=3)=[C:13]3[C:8]([C:9]([F:23])=[CH:10][CH:11]=[CH:12]3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:6]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[C:13]3[C:8]([C:9]([F:23])=[CH:10][CH:11]=[CH:12]3)=[N:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

反応物 3

HCID 8079Cyclohexene

HCID 25134Boron tribromide

HCID 115005622-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-2H-indazole

生成物 1

HCID 1354539644-(2-cyclopentyl-7-fluoro-2H-indazol-3-yl)phenol収率 57.2%

実験手順

Prepared according to Method D step C from 2-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-2H-indazole (0.055 g, 0.177 mmol), boron tribromide (0. 70 mL, 0.74 mmol) and 0.3 mL of cyclohexene to give the product (0.03 g) as an amber solid.