Cyclohexene → 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)benzene-1,3-diol

反応式

[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][C:17]=3[O:24]C)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][C:17]=3[OH:24])=[N:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

反応物 3

HCID 8079Cyclohexene

HCID 25134Boron tribromide

HCID 688823241-cyclopentyl-3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

生成物 1

HCID 1363584614-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)benzene-1,3-diol収率 78.4%

実験手順

Prepared according to Method D step C from 1-cyclopentyl-3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.225 g, 0.6 mmol), boron tribromide (0.5 mL, 5 mmol) and 1.0 mL of cyclohexene to give the product (0.147 g) as a white solid.