化工社化工社 化学情報印刷レポート · 研究参考用
Methylhydrazine → 3-(4-Chlorophenyl)-1-Methyl-1H-Pyrazol-5-Amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylhydrazine | HCID 6061 | — |
| 反応物 | 4-Chlorobenzoylacetonitrile | HCID 138308 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(4-Chlorophenyl)-1-Methyl-1H-Pyrazol-5-Amine | HCID 2735304 | 46% |
反応手順
A solution of 3-(4-Chloro-phenyl)-3-oxo-propionitrile (1.8 g, 10 mmol) and N-Methylhydrazine (1 mL, excess) in EtOH (30 mL) was stirred to reflux 3 hours. After cooling the precipitate was filtered off, to give the title compound (950 mg, 4.6 mmol) as white crystals in a 46% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07241793B2 |
| 出典データセット | uspto-grants-2007_07 |
| ORD ID | ord-5b329b88a7da4a85ba665c7e2a106894 |
| 出典メモ | uspto-grants-2007_07 |