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4-Nitrophenyl chloroformate → 4-Nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride

HRID 1295431
ノート
印刷プレビュー

反応式

HRID 1295431 の反応式
[Cl:1]C1C=C2C(=C(Cl)C=1)CN(C)CC2C1C=C(N)C=CC=1.[Cl:21][C:22]1[CH:23]=[C:24]2[C:29](=[C:30]([Cl:32])[CH:31]=1)[CH2:28][N:27]([CH3:33])[CH2:26][CH:25]2[C:34]1[CH:35]=[C:36]([NH:40][C:41](=[O:52])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[CH:37]=[CH:38][CH:39]=1.ClC1C=C2C(=C(Cl)C=1)CN(C)CC2C1C=CC([C@@](O)([C@@H](O)[C@H](O)[C@H](O)CO)C(N)=O)=CC=1.ClC([O:88][C:89]1[CH:94]=[CH:93][C:92]([N+:95]([O-:97])=[O:96])=[CH:91][CH:90]=1)=O>ClCCl>[ClH:1].[Cl:21][C:22]1[CH:23]=[C:24]2[C:29](=[C:30]([Cl:32])[CH:31]=1)[CH2:28][N:27]([CH3:33])[CH2:26][CH:25]2[C:34]1[CH:35]=[C:36]([NH:40][C:41](=[O:52])[O:88][C:89]2[CH:94]=[CH:93][C:92]([N+:95]([O-:97])=[O:96])=[CH:91][CH:90]=2)[CH:37]=[CH:38][CH:39]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 821294-Nitrophenyl chloroformate2 回HCID 98361943-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)anilineHCID 11213884N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamideHCID 69511913[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide

生成物 1

HCID 22386892
4-Nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

350 mg (1.1 mmol) of 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example compound 2, intermediate 1) were dissolved in 17.5 ml of dichloromethane and admixed with stirring with 230 mg (1.1 mmol) of 4-nitrophenyl chloroformate. After 4.5 hours, a further 0.1 equivalent (23 mg) of 4-nitrophenyl chloroformate was added and the solution was stirred overnight. For workup, the resulting precipitate was filtered off and washed with dichloromethane. The crude product obtained in this way could be reacted further without further purification.

後処理

  1. filtrationFor workup, the resulting precipitate was filtered off
  2. washwashed with dichloromethane

出典と根拠

ORDレコード
ord-3fb6f50621124956a0f1f53efef6829b
出典データセット
uspto-grants-2007_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07241775B2

反応ノート

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