Ammonium Hydroxide → 6-Iodoquinolin-2-amine
反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([I:12])[CH:8]=2)[N:3]=1.[OH-].[NH4+:14]>>[I:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH2:14])[CH:11]=[CH:10]2参加物
3
反応条件
- 温度
- 140 °C
実験手順
A suspension of 2-chloro-6-iodo-quinoline (1 g, 3.46 mmol) in ammonium hydroxide (28%, 20 mL) was heated at 140° C. for 3 days under pressure tube. After cooling, the solvent was removed by rotary evaporator. The solid was collected by filtration, washed with water and dried to obtain 6-iodo-quinolin-2-ylamine (0.78 g, 84%) as a black solid. LC-MS m/e 271 (MH+).
後処理
- temperatureAfter cooling
- customthe solvent was removed by rotary evaporator
- filtrationThe solid was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-87a922d782d44d1ca0046e31f953c470
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07241893B2
反応ノート
読み込み中…