4,4'-Dibromobiphenyl → Ethyl (3ar,6ar)-1-(4'-bromo-1,1'-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1h)-carboxylate

The catalyst solution was added to the vessel containing the 4,4′-dibromobiphenyl, cesium carbonate, and the product of Example 41C and the mixture was heated to 98° C. for 12 hours. The mixture was cooled to 20° C. and 80 g of dichloromethane was added. The resulting mixture was stirred and then filtered to remove the catalyst. The resulting solution was concentrated under reduced pressure and the residue was purified by column chromatography to yield 5.65 g of the title compound.

1. additionThe catalyst solution was added to the vessel
2. filtrationfiltered
3. customto remove the catalyst
4. concentrationThe resulting solution was concentrated under reduced pressure
5. customthe residue was purified by column chromatography

ORDレコード

ord-16e4cf9df1dd43729c103249a4a05ff9

出典データセット

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07728031B2