2-Amino-6-fluorobenzylamine → HCID 178432155、化合物
反応式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][NH2:5].[CH2:11](C(CC)(CC)C([O-])([O-])[O-])[CH3:12]>C(O)C>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]2[C:3]=1[CH2:4][NH:5][C:11]([CH3:12])=[N:1]2参加物
4
実験手順
A solution of 2-amino-6-fluorobenzylamine (1.1 g, 7.86 mmol) and triethylorthoacetate (1.58 mL, 8.64 mmol) in ethanol (30 mL) was heated at 80° C. for 14 h. The reaction mixture was allowed to cool to room temperature and evaporated in vacuo. The yellow oil was triturated with diethyl ether to give the title compound as white solid (0.74 g, 57%). Mass spectrum (API+): Found 165 (MH+). C9H9N2F requires 164.
後処理
- customevaporated in vacuo
- customThe yellow oil was triturated with diethyl ether
出典と根拠
- ORDレコード
- ord-883b5f5678a0494db9e22991200cba7a
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07244726B2
反応ノート
読み込み中…