Hydrochloric Acid → HCID 23105929、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:12]C=O)([CH3:11])[CH3:10])=[CH:4][C:3]=1[C:15]([F:18])([F:17])[F:16].Cl.C(=O)([O-])[O-].[K+].[K+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:4][C:3]=1[C:15]([F:16])([F:17])[F:18]参加物
5
実験手順
3.30 g (12.5 mmol) N-[2-(4-fluoro-3-trifluoromethyl-phenyl)-1,1-dimethyl-ethyl]-formamide are combined with 25 mL water and 25 mL conc. hydrochloric acid and refluxed for 2 hours. The reaction mixture is diluted with water, made alkaline with potassium carbonate solution and extracted with dichloromethane. The combined organic phases are dried with sodium sulphate and freed from solvent. Brown oil.
後処理
- temperaturerefluxed for 2 hours
- extractionextracted with dichloromethane
- dry with materialThe combined organic phases are dried with sodium sulphate
出典と根拠
- ORDレコード
- ord-99036bfeb5374e259b7fbebfb6293ad3
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07244728B2
反応ノート
読み込み中…