Hydrochloric Acid → HCID 15225578、化合物

HRID 129564ノート

反応式

HRID 129564 の反応式
C[O:2][CH:3](OC)[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]2[N:17]=[N:18][N:19]([C:21]([CH3:29])([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH3:22])[N:20]=2)=[CH:6][CH:5]=1.Cl.O>CO>[CH3:29][C:21]([N:19]1[N:18]=[N:17][C:16]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:7]2[CH:6]=[CH:5][C:4]([CH:3]=[O:2])=[CH:9][CH:8]=2)=[N:20]1)([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[CH3:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 111124504-dimethoxymethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl

生成物 1

HCID 15225578HCID 15225578、化合物収率 97.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-dimethoxymethyl-2'-[2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl]biphenyl (2.9 g, 7.0 mmol) and 15 mL of 4M hydrochloric acid in 50 mL of methanol was stirred at room temperature for 18 hours. The mixture was diluted with 200 mL of diethyl acetate and poured into 300 mL of water. The ethyl acetate layer was washed 3 times with water, dried over magnesium sulfate and concentrated giving a white, waxy solid (2.51 g). A portion of the solid (1.53 g) was crystallized from diethyl ether and isolated. Drying gave 2'-[2-(1-methyl-1-phenylethyl)biphenyl-2H-tetrazolebiphenyl-4-carbaldehyde (1.2 g, 3.2 mmol), m.p. 98.5°-97° C.

後処理

  1. washThe ethyl acetate layer was washed 3 times with water
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-221d9271be6d4d36ad99a6fadaaec73f
出典データセット
uspto-grants-1995_11
特許番号
US05468867

反応ノート

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