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Sodium Chloride → 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | 1,4-Butanediol | HCID 8064 | — |
| 反応物 | 1,2,4,5-Tetrafluorobenzene | HCID 9474 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol | HCID 69364663 | — |
反応手順
To a mixture of 1,4-butanediol (15 g, 0.17 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mmol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo giving the title compound. This material was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07244722B2 |
| 出典データセット | uspto-grants-2007_07 |
| ORD ID | ord-663d6016ba36490f8673a3c4952bbb51 |
| 出典メモ | uspto-grants-2007_07 |