化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Chloride → 3-(2,4,5-Trifluoro-phenoxy)propan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | 1,2,4,5-Tetrafluorobenzene | HCID 9474 | — |
| 反応物 | 1,3-Propanediol | HCID 10442 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-(2,4,5-Trifluoro-phenoxy)propan-1-ol | HCID 69365631 | — |
反応手順
To a mixture of 1,3-propanediol (15 g, 0.20 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo to the title compound that was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07244722B2 |
| 出典データセット | uspto-grants-2007_07 |
| ORD ID | ord-04fab01c7dfb40d0b7ee845903b92f4c |
| 出典メモ | uspto-grants-2007_07 |