関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isoamyl Nitrite | HCID 8053 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Methyl 2-aminothiazole-5-carboxylate | HCID 238005 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 1,3-thiazole-5-carboxylate | HCID 331117 | 48.5% |
反応手順
The mixture of 2.15 g of isoamyl nitrite and 10 ml of dioxane was stirred at 80° C. under a nitrogen atmosphere. A solution of 1.23 g of 2-aminothiazole-5-carboxylic acid methyl ester (7-3) in 20 ml of dioxane was added drop wise. The mixture was refluxed for 2 hours. After cooling to room temperature 30 ml of ethyl acetate was added. The mixture was washed with brine and dried and the solvent evaporated under reduced pressure. The crude product is purified on silica, thus yielding 0.54 g (48%) of thiazol 5-carboxylic acid methyl ester (7-4).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07244752B2 |
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| 出典データセット | uspto-grants-2007_07 |
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| ORD ID | ord-372d32bb21b14d429e50cd966c65ddb0 |
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| 出典メモ | uspto-grants-2007_07 |
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