Ammonium Chloride → 2-[5-Bromo-3-(dimethylamino)-2-methoxyphenyl]-2-propanol

HRID 1295968ノート

反応式

HRID 1295968 の反応式
[CH3:1][Mg]Br.[Br:4][C:5]1[CH:6]=[C:7]([N:16]([CH3:18])[CH3:17])[C:8]([O:14][CH3:15])=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=1.[Cl-].[NH4+]>CCOCC>[Br:4][C:5]1[CH:6]=[C:7]([N:16]([CH3:18])[CH3:17])[C:8]([O:14][CH3:15])=[C:9]([C:11]([OH:13])([CH3:1])[CH3:12])[CH:10]=1

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 229296931-[5-Bromo-3-(dimethylamino)-2-methoxyphenyl]-1-ethanoneHCID 178418573HCID 178418573、化合物

生成物 1

HCID 589100492-[5-Bromo-3-(dimethylamino)-2-methoxyphenyl]-2-propanol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
-70 °C

実験手順

A solution of methylmagnesium bromide in ether was added to a solution of 1-[5-bromo-3-(dimethylamino)-2-methoxyphenyl]-1-ethanone (4 g) in diethyl ether while stirring at −70° C. After stirring at the same temperature for 30 minutes, saturated aqueous ammonium chloride was added, extraction was performed with ethyl acetate, and the organic layer was washed with brine and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to yield the title compound (3.4 g) as an oil.

後処理

  1. stirringAfter stirring at the same temperature for 30 minutes
  2. extractionextraction
  3. washthe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-666d40200f8546c88de9a9136b22a148
出典データセット
uspto-grants-2007_07
特許番号
US07244730B2

反応ノート

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