HCID 131726535、化合物 → HCID 131726536、化合物
反応式
C(OC([NH:8][C@@:9]([CH3:26])([C:17]([NH:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C>Cl.O1CCOCC1>[CH3:26][C@:9]([C:17]([NH:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[O:18])([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH2:8]参加物
4
実験手順
[N-(tert-butyloxycarbonyl)-α-methyl-(R)-phenylalanyl]glycine, ethyl ester was stirred at ambient temperature in 4N HCl in dioxane (30 ml). After 1.5 h, the solvent was removed in vacuo. The residue was transferred to a separatory funnel with EtOAc. Extraction with EtOAc (2×) and washing of the combined organic layers brine and drying with MgSO4 afforded 0.63 g of crude product after evaporation of the solvent. This was used in the next step without further purification. MS (ESI) 265 (M+H).