Acetic Acid → 1-acetylamino-3-adamantanol

HRID 1296366

反応式

HRID 1296366 の反応式
[C:1]([NH:4][C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2)(=[O:3])[CH3:2].[OH:15]N1C(=O)C2=CC=CC=C2C1=O.[C:27]([OH:30])(=[O:29])[CH3:28]>[V+3]>[C:1]([NH:4][C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][C:7]([OH:15])([CH2:8]3)[CH2:6]1)[CH2:12]2)(=[O:3])[CH3:2].[C:1]([NH:4][C:5]12[CH2:28][C:27]3([OH:30])[CH2:10][CH:11]([CH2:13][C:7]([OH:15])([CH2:8]3)[CH2:6]1)[CH2:12]2)(=[O:3])[CH3:2].[C:1]([NH:4][C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([C:8]3=[O:29])[CH2:6]1)[CH2:12]2)(=[O:3])[CH3:2]

参加物

7

反応物 3

HCID 176Acetic AcidHCID 10665N-HydroxyphthalimideHCID 64153Acetamide, N-tricyclo[3.3.1.13,7]dec-1-yl-

生成物 3

HCID 28427921-acetylamino-3-adamantanolHCID 5338964N-(4-oxo-1-adamantyl)acetamideHCID 22463599HCID 22463599、化合物

試薬・触媒・溶媒 1

HCID 178528047HCID 178528047、化合物触媒

実験手順

Mixture of 10 mmole 1-acetylaminoadamantane (Aldrich chemical Company, Inc.), 1 mmole of N-hydroxyphthalimide (NHPI), 0.05 mmole of vanadium (III) acetylacetonato (V(AA)3) and 25 mL of acetic acid was stirred under an oxygen atmosphere and the conditions represented in Table 1 (temperature and time). The products in the reaction mixture were analyzed by gas chromatography, and, as a result, 1-acetylamino-3-adamantanol (compound 1), 1-acetylamino-3,5-adamantanediol (compound 2) and 1-acetylamino-4-adamantanone (compound 3) were obtained with conversions and yields represented in Table 1.

出典と根拠

ORDレコード
ord-dcd126749f3d4ea2b0d061a0a837bdbc
出典データセット
uspto-grants-2007_07
特許番号
USRE039744E1

関連ノート

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