Potassium Carbonate → HCID 69155336、化合物
反応式
C([O:4][C@H:5]([CH3:29])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:18](=[O:19])[C:17]2[N:16]3[CH2:20][CH2:21][N:22]([CH2:23][O:24][CH2:25][CH3:26])[C:15]3=[N:14][C:13]=2[N:12]([CH3:27])[C:11]1=[O:28])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:25]([O:24][CH2:23][N:22]1[C:15]2=[N:14][C:13]3[N:12]([CH3:27])[C:11](=[O:28])[N:10]([CH2:9][CH2:8][CH2:7][CH2:6][C@H:5]([OH:4])[CH3:29])[C:18](=[O:19])[C:17]=3[N:16]2[CH2:20][CH2:21]1)[CH3:26]参加物
4
実験手順
A mixture of (R)-3-(5-acetoxyhexyl)-7,8-dihydro-8-ethoxymethyl-1-methyl-1H-imidazo[2,1-f]-purine-2,4(3H,6H)-dione (100 mg, 0.245 mmol) and potassium carbonate (51 mg, 0.368 mmol) in methanol (12 ml) was stirred at room temperature for 16 hours. After concentration under reduced pressure, the residue was treated with 1.0 M aqueous ammonium chloride solution (10 ml) and stirred for 1 hour. The solid was filtered, washed with water, and dried under vacuum to provide (R)-7,8-dihydro-8-ethoxymethyl-3-(5-hydroxyhexyl)-1-methyl-1H-imidazo[2,1-f]-purine-2,4(3H,6H)-dione (60 mg, 67% yield) as a white powder.