Piperazine → HCID 18186824、化合物

反応式

Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.O(CCCCCO)C1C=CC=CC=1.[NH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.C([O-])([O-])=O.[K+].[K+]>>[O:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[N:3]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

反応物 4

HCID 4837Piperazine

HCID 11430Potassium Carbonate

HCID 12293201HCID 12293201、化合物

HCID 18186774HCID 18186774、化合物

生成物 1

HCID 18186824HCID 18186824、化合物

実験手順

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[(5-phenoxypentyl)oxy]pyrazine (2.06 g, 7.03 mmol; obtained according to the procedure of example 50, step 1, starting from 5-phenoxy-1-pentanol*), piperazine (1.88 g, 21.8 mmol) and K2CO3 (0.97 g, 7.03 mmol). The yield of the title compound was 1.15 g (48%) which was obtained as a white solid. Purity 100% (HPLC). MS m/z 343 (M+H)+. HRMS m/z calcd for C19H26N4O2 (M)+ 342.2056, found 342.2054. *Described in. J. Org. Chem. 1968, 33, 2271-2284.