3,5-Dimethoxybenzyl alcohol → 2-Chloro-6-[(3,5-Dimethoxybenzyl)Oxy]Pyrazine

HRID 1296664

反応式

HRID 1296664 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[CH2:6][OH:7].[Cl:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=1>>[Cl:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16]([O:7][CH2:6][C:5]2[CH:8]=[C:9]([O:11][CH3:12])[CH:10]=[C:3]([O:2][CH3:1])[CH:4]=2)[N:15]=1

参加物

3

反応物 2

HCID 697183,5-Dimethoxybenzyl alcoholHCID 785042,6-Dichloropyrazine

生成物 1

HCID 181868872-Chloro-6-[(3,5-Dimethoxybenzyl)Oxy]Pyrazine

実験手順

The title compound was prepared according to the procedure of example 50, step 1, starting from 3,5-dimethoxybenzyl alcohol (2.16 g, 12.8 mmol), K-t-BuO (1.34 g, 11.9 mmol) and 2,6-dichloropyrazine (1.59 g, 10.7 mmol). The yield of the title compound was 2.56 g (84%) and was obtained as a white solid. HRMS m/z calcd for C13H13ClN2O3 (M)+ 280.0615, found 280.0627. Anal. (C13H13CIN2O3) C, H, N.

後処理

  1. customThe title compound was prepared
  2. customwas obtained as a white solid

出典と根拠

ORDレコード
ord-87613d3197534cebab34488f00b45aa7
出典データセット
uspto-grants-2007_07
特許番号
US07247633B2

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