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Piperazine → 2-[{4-(2-Pyridinyl)Benzyl}Oxy]-6-(1-Piperazinyl)Pyrazine

HRID 1296669
ノート
印刷プレビュー

反応式

HRID 1296669 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:12][CH:11]=2)[N:3]=1.N1C=CC=CC=1C1C=CC(CO)=CC=1.[NH:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.C([O-])([O-])=O.[K+].[K+].N1C=CC=CC=1C1C=CC(C=O)=CC=1>>[N:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:13]1[CH:14]=[CH:15][C:10]([CH2:9][O:8][C:4]2[CH:5]=[N:6][CH:7]=[C:2]([N:36]3[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]3)[N:3]=2)=[CH:11][CH:12]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 5

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 1515239(4-(Pyridin-2-yl)phenyl)methanolHCID 15152404-Pyridin-2-ylbenzaldehydeHCID 181869352-Chloro-6-[{4-(2-pyridinyl)benzyl}oxy]pyrazine

生成物 1

HCID 181869372-[{4-(2-Pyridinyl)Benzyl}Oxy]-6-(1-Piperazinyl)Pyrazine

実験手順

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[{4-(2-pyridinyl)benzyl}oxy]pyrazine (2.73 g, 9.16 mmol; obtained according to the procedure of example 50, step 1, starting from 4-(2-pyridinyl)benzyl alcohol*), piperazine (2.41 g, 27.9 mmol) and K2CO3 (1.33 g, 9.62 mmol) with the exception that the final filtration through alumina was omitted. The yield of the of the title compound was 2.06 g (65%) which was obtained as a beige colored oil that solidified when refrigerated. Purity 100% (HPLC). MS m/z 347 (M)+. HRMS m/z calcd for C20H21N5O (M)+ 347.1746, found 347.1749. *Obtained by reduction (NaBH4) of 4-(2-pyridyl)benzaldehyde.

後処理

  1. customobtained
  2. filtrationfiltration through alumina
  3. customwas obtained as a beige colored oil that solidified when refrigerated

出典と根拠

ORDレコード
ord-b295db703f8c42608a69355c3bbef798
出典データセット
uspto-grants-2007_07
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07247633B2

反応ノート

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